Arteriosclerosis Obliterans (2025)

The underlying mechanism of ASO is heavily tied to the biological processes of aging and lifestyle stress.

: As these fibrous plaques calcify and thicken, the vessel diameter narrows, severely obstructing distal blood flow. ⚠️ Major Risk Factors

: Excess LDL ("bad") cholesterol deposits in the damaged walls, triggering inflammatory reactions.

: Pathologically, the lesion is marked by the thinning or destructive degeneration of the tunica media.

: Chronic high blood pressure, smoking, or hyperglycemia damages the inner lining of the artery.

. Triggered by the buildup of atherosclerotic plaques within the arterial intima, it leads to restricted blood flow and severe limb ischemia. It typically affects the lower abdominal aorta, the iliac arteries, and the arteries supplying the legs. 🧬 Pathophysiology