: Sensitization through inflamed skin can lead to early-onset food allergies.
: These cells produce cytokines (IL-4, IL-13) that trigger B cells to differentiate into plasma cells producing allergen-specific IgE.
: Systemic immune priming eventually leads to upper and lower airway inflammation. 3. Key Management Strategies : Sensitization through inflamed skin can lead to
: Often the first sign in infancy, caused by skin barrier defects (e.g., filaggrin mutations) that allow for epicutaneous allergen sensitization.
While there is currently no cure, management focuses on controlling inflammation and restoring barrier function. Atopy - StatPearls - NCBI Bookshelf - NIH Atopy - StatPearls - NCBI Bookshelf - NIH
The core of atopy is a Type I hypersensitivity reaction driven by a Type 2 immune response.
: Antigen-presenting cells perceive allergens (like pollen or dust mites) as danger signals, activating TH2 or ILC2 cells. caused by skin barrier defects (e.g.
Atopy typically follows a predictable chronological progression: