His work continues to influence major research institutions, including the University of Michigan Medical School , where the study of cardiovascular disease and lipid metabolism remains a primary focus of the Frankel Cardiovascular Center . Daniel Steinberg, 1922–2015 - PMC - NIH

: This hypothesis remains a central pillar of cardiovascular medicine, having inspired over 8,000 follow-up papers from laboratories worldwide. Clinical Leadership and the Cholesterol Trials

Beyond laboratory work, Steinberg was a critical force in proving that lowering cholesterol actually saves lives. He served as the for the Lipid Research Clinics Coronary Primary Prevention Trial , the first major study to demonstrate that drug-induced lipid lowering could reduce heart attacks.

: His research showed that oxidized LDL is proinflammatory and immunogenic, explaining the inflammatory nature of arterial lesions.