An isolated prolongation of the activated partial thromboplastin time (aPTT) that does not correct when mixed with normal plasma.
Sudden, severe bruising (ecchymosis), mucosal bleeding, or prolonged bleeding after delivery.
Used to stop active bleeding by circumventing the inhibited Factor VIII. Download HГ©mophilie acquise grossesse pdf
The primary goal is to stop the body from producing the antibodies.
Acquired Hemophilia A (AHA) related to pregnancy is a rare but life-threatening autoimmune disorder where the body develops antibodies against its own clotting Factor VIII. Unlike hereditary hemophilia, which is genetic, this form typically appears in women with no prior history of bleeding. It most commonly occurs in the , often 1 to 4 months after delivery. Key Features & Diagnosis The primary goal is to stop the body
High-dose corticosteroids (Prednisone) are the standard first step, sometimes combined with Cyclophosphamide or Rituximab.
Diagnosis is often delayed because it is so rare, occurring in roughly 1 to 1.5 cases per million people annually. It most commonly occurs in the , often
Treatment requires a multidisciplinary approach involving hematologists, obstetricians, and neonatologists. Controlling Bleeding