: Associated JAKs transphosphorylate and activate each other.
: Phosphorylated STATs dissociate and form dimers. Download Les inhibiteurs JAK STAT pdf
: STAT proteins bind to these sites and are themselves phosphorylated by JAKs. : Associated JAKs transphosphorylate and activate each other
: STAT dimers translocate to the nucleus to regulate gene expression. Basic Mechanisms of JAK Inhibition - PMC - NIH Download Les inhibiteurs JAK STAT pdf