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Primary splenic lymphomas account for less than 1% of all non-Hodgkin lymphomas (NHL). Unlike nodal lymphomas, these diseases typically present with massive splenomegaly without significant lymphadenopathy. Accurate diagnosis is critical, as treatment varies significantly from other B-cell malignancies. 2. Classification of Splenic B-Cell Lymphomas
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The most frequent type, often associated with a "villous" lymphocyte morphology in blood smears. Primary splenic lymphomas account for less than 1%
Treatment is indicated only for symptomatic patients (progressive cytopenia or painful splenomegaly). Download Lymphomes splГ©niques pdf
Asymptomatic patients can often be monitored for years.
In cases associated with HCV infection, antiviral therapy can lead to lymphoma regression. 6. Conclusion
Splenic Lymphomas: Pathophysiological Characteristics, Diagnosis, and Management