Gigp-40.mp4

Neurons regulate glycolysis dynamically in response to metabolic stress.

Glycogen serves as a direct fuel source to sustain glycolytic plasticity and synaptic function in vivo. The inability to utilize GDGP is associated with deficiencies in synaptic vesicle recycling during hypoxia. GIGP-40.mp4

What is the (e.g., a technical lecture, a biological study, a project update)? a technical lecture

The enzyme PYGL-1 is necessary for this metabolic flexibility. a biological study

Traditionally, neurons were thought to rely primarily on blood-glucose-derived glucose, with astrocytes managing glycogen storage. However, evidence now indicates that neurons can engage in their own glycogen-dependent glycolytic plasticity (GDGP) to meet sudden metabolic demands. This paper investigates how GDGP operates, specifically in mitigating the effects of mitochondrial dysfunction. Findings on GDGP Mechanisms