: Normally, the RAR works with another protein (RXR) to bind to DNA. The R383 area is part of the machinery that ensures genes are only turned on when the proper signal (ligand) is present.

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: In certain medical conditions like Resistance to Thyroid Hormone (RTH) syndrome, a mutation at this specific spot (R383) impairs the receptor's ability to release "corepressors".

: The switch does not lock in forward or reverse, allowing you to spin it quickly like a thumb screw to tighten loose fasteners.

(often stylized with a trailing 'R' or 'rar' in search terms) is a popular .