The series begins three years after October 14, 2011, the day 140 million people disappeared. Unlike typical post-apocalyptic shows, it focuses on the internal lives and grief of those left behind rather than the science of the event.

Described by some as the biblical Rapture, the event is completely random, claiming babies, world leaders, and criminals alike without a discernible pattern.

The series features an acclaimed ensemble cast led by Justin Theroux and Carrie Coon.