The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane.
Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power tm,cc,jp
It tethers vesicles to the plasma membrane, facilitating sound encoding. The binding requires cooperation between multiple C2 domains
The study highlights that membrane binding involves a cooperative effort of multiple domains. The protein utilizes C2 domains to bridge synaptic
The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane").
Lack of functional otoferlin or its C2 domain interaction prevents proper vesicle docking, leading to profound deafness. Summary Table: Otoferlin C2 Interactions Function/Location C2B-C2G Main interface for membrane binding C2D Crucial Ca 2+raised to the 2 plus power binding site; mutations affect sound encoding C2F-C2G Rearrange upon membrane binding to close structure Target Membrane Membrane where vesicles are docked
This molecular mechanism allows the ear to convert sound into neural signals at incredibly high speeds.